Palmitoylethanolamide is a fatty acid amide that is naturally present in our bodies. It mainly functions as a very comprehensive anti-inflammatory and pain reducer. In terms of pain reduction, it works great for individuals with neuropathic pain and produces significant back pain relief and sciatic pain relief. This is due to the fact that palmitoylethanolamide produces something called the ‘Entourage Effect’ an effect which potentiates the effects of Anandamide and it is naturally present in our bodies. Anandamide plays a crucial role in inflammation and pain perception, and Palmitoylethanolamide prevents the breakdown of anandamide and works to enhance its effects in the body. This pathway is especially effective at decreasing neuropathic pain and thus palmitoylethanolamide is very popular with people looking for sciatic pain relief and back pain relief.

Palmitoylethanolamide also works to decrease inflammation by interacting with an enzyme called cyclooxygenase 2 (COX-2). This enzyme produces inflammation and is the target of most NSAIDs like Ibuprofen. These NSAIDs decrease pain perception by blocking COX-2 activity, whereas palmitoylethanolamide decreases pain perception by preventing the production of proinflammatory compounds that are produced by COX-2, such as prostaglandins D2 and E2.

Another unique effect that palmitoylethanolamide has, is that it activates the PPAR-alpha receptor. This receptor a major mediator of inflammation and pain perception and its activation causes a decrease in inflammation and a subsequent drop in pain perception.

Altogether, palmitoylethanolamide is a great compound for neuropathic pain and is a fantastic choice for individuals looking for sciatic pain relief and back pain relief.

Product Features

  • FAST NATURAL PAIN RELIEF. Pea is naturally occuring in the body. Pea has been found in multiple studies to quickly aid with pain. Research indicates it may be vital to the bodies natural pain response.
  • EFFECTIVE INFLAMMATION SUPPORT. Pea has been shown to potentially be beneficial for relief of chronic pain including neuropathic, back, sciatic pain.
  • LAB TESTED AND VERIFIED – All Nootropics Depot products are thoroughly lab tested to ensure our customers are receiving only the highest quality ingredients at the optimal strength, potency and purity.

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